Endocrine Abstracts

Background: Gestational diabetes mellitus (GDM) is known to predispose offspring to metabolic diseases. However, the underlying mechanisms has not been thoroughly studied yet. The glucocorticoid receptor gene or nuclear receptor sub-family 3, group C, member 1 (NR3C1) may predispose to type 2 diabetes mellitus, metabolic syndrome and depression. NR3C1 gene showed significantly decreased methylation levels in cord blood and placenta from GDM women compared wit...

Background: Understanding the mechanism whereby the intrauterine hyperglycemia in women with gestational diabetes mellitus (GDM) affects the offspring’ predisposition to metabolic and cardiovascular diseases may help prevent their intergenerational transmission. Our aim was to study the effect of the degree and duration of maternal hyperglycemia on the level of expression of genes associated with cardio-metabolic diseases in human umbilical vein endothelial cells (HUVECs)...